Association of Phosphodiesterase 4D Gene With Ischemic Stroke in a Pakistani Population
نویسندگان
چکیده
منابع مشابه
Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population.
BACKGROUND AND OBJECTIVES Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D (PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology of the disease. In this study, we aimed at investigating the association between 3 polymorphisms of the PDE4D gene and ischemic stroke ...
متن کاملAssociation of phosphodiesterase 4D polymorphisms with ischemic stroke in a US population stratified by hypertension status.
BACKGROUND AND PURPOSE Phosphodiesterase 4D (PDE4D) underlies the STRK1 linkage peak for stroke on chromosome 5q12 identified in Iceland. We tested association of 13 single-nucleotide polymorphisms (SNPs) and 1 microsatellite in a nested case-control sample of elderly white women (>65 years of age) from the Study of Osteoporotic Fractures (SOF) in the United States. METHODS The genotypes of 2...
متن کاملAssociation of Phosphodiesterase 4D with ischemic stroke: a population-based case-control study.
BACKGROUND AND PURPOSE The Phosphodiesterase 4D (PDE4D) gene was reported recently to be associated with ischemic stroke in an Icelandic population. The association was found predominately with large vessel and cardioembolic stroke. However, 2 recent reports were unable to confirm this association, although a trend toward association with cardioembolic stroke was reported. None of the reports i...
متن کاملPhosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population
Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and ischemic stroke was explored in a case-control study of 205 consecutive Korean patients with noncardiogenic ischemic stroke and 103 healthy controls who wer...
متن کاملPhosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis.
BACKGROUND AND PURPOSE Phosphodiesterase 4D (PDE4D) was identified recently as the first novel stroke gene to predispose to ischemic stroke independently of conventional risk factors. An association was only found with large vessel and cardioembolic stroke, suggesting a mechanism of accelerated atherosclerosis. We sought to replicate this association in ischemic stroke as a whole, and individua...
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ژورنال
عنوان ژورنال: Stroke
سال: 2005
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000182242.59466.ee